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用放射免疫方法测定了１６名口腔粘膜鳞癌患者肿瘤组织、癌旁正常口腔粘膜组织、外周血浆及１６名正常人外周血浆中ｃＡＭＰ和ｃＧＭＰ含量，并初步探讨了ＣＡＭＰ、ｃＧＭＰ与口腔鳞癌发病的关系。结果显示：与对照组相比，鳞癌患者癌组织中的ｃＡＭＰ水平显著降低（Ｐ＜０．０１），ｃＧＭＰ含量升高（Ｐ＜０．０５），ｃＡＭＰ／ＣＧＭＰ比值下降（Ｐ＜０。０５），而血浆中的ｃＡＭＰ、ｃＧＭＰ含量则无明显改变（Ｐ＞０．０５）．本研究结果提示口腔鳞癌组织中存在有ｃＡＭＰ、ｃＧＭＰ含量与代谢的异常。这可能与口腔鳞癌的发生、发展等有关，并对研究口腔癌肿的发病机制有一定实际意义。
The levels of cAMP and cGMP in peripheral blood of 16 oral mucosal squamous cell carcinoma patients, adjacent normal mucosa tissues, peripheral plasma and 16 normal persons were measured by radioimmunoassay, and the relationship between CAMP, cGMP and oral squamous cell carcinoma Relationship. The results showed that compared with the control group, the cAMP level was significantly decreased (P <0.01), the cGMP level was increased (P <0.05) and the cAMP / CGMP ratio was decreased (P <0. 05), while plasma cAMP, cGMP content was no significant change (P> 0.05). The results suggest that there are cAMP, cGMP content and metabolic abnormalities in oral squamous cell carcinoma. This may be related to the occurrence and development of oral squamous cell carcinoma and so on, and to study the pathogenesis of oral cancer has some practical significance.