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目的探讨双侧丘脑底核脑深部电刺激对帕金森病患者抑郁状况的影响。方法设置STN-DBS组及药物治疗对照组,配对入组,有效病例27对。两组患者均只服用左旋多巴制剂且剂量前后无显著变化,均未服用抗抑郁药物。前后共6次分别评估其抑郁及运动状况。结果与术前及药物治疗组相比,STN-DBS组术后运动功能改善,抑郁状况短期内(3～6个月)改善;STN-DBS组术后运动评分与抑郁评分短期内(5周～6个月)相关,双侧电压均值与其抑郁评分均相关;STN-DBS组术后电压均值对抑郁评分的标准回归方程及回归系数均显著,运动评分对抑郁评分的标准回归方程及回归系数在短期内(5周～3个月)显著。结论STN-DBS对PD患者运动障碍症状的改善在短期内可改善其抑郁状况,但长期效应不明显。在STN-DBS治疗电压值范围内,双侧电压均值越高,PD患者的抑郁状况越严重。
Objective To investigate the effect of bilateral deep subthalamic nucleus electric stimulation on the depression of Parkinson’s disease patients. Methods The STN-DBS group and the drug treatment control group were set up and paired into groups, with 27 valid cases. Both groups took only levodopa preparations and no significant changes before and after the dose, did not take antidepressants. Before and after a total of 6 times to assess their depression and exercise status. Results The postoperative motor function of STN-DBS group was improved and the depression status was improved in a short period (3-6 months) compared with preoperative and drug-treated groups. Short-term postoperative exercise score and depression score in STN-DBS group (5 weeks ~ 6 months), the mean voltage of both sides was correlated with their depression scores. The standard regression equation and regression coefficient of postoperative mean voltage to depression score in STN-DBS group were significant. The standard regression equation of motor score to depression score and regression coefficient In the short term (5 weeks to 3 months) significant. Conclusion STN-DBS can improve the symptoms of dyskinesia in PD patients in a short period of time, but the long-term effects are not obvious. In the treatment of STN-DBS voltage range, the higher the bilateral voltage mean PD patients with more severe depression.