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目的探讨检测血小板四项指标水平在病毒性肝炎患者诊治中的临床意义。方法选择2012年5月—2014年8月在衢州市人民医院接受治疗的病毒性肝炎患者180例,作为本次研究的观察组,并根据其病情分为:急性肝炎组45例,慢性活动性肝炎组40例,重型肝炎组51例,肝炎肝硬化组44例,另外选择同期的健康体检者80例作为对照组。检测并记录各组受检者的血小板计数(PLT)、血小板比积(PCT)、血小板体积分布宽度(PDW)以及平均血小板体积(MPV),进行统计分析,并分析其与患者的免疫球蛋白水平、门脉高压以及出血病症间的相关性。结果对照组的血小板四项指标水平明显优于观察组,差异具有统计学意义(P<0.05);急性肝炎和慢性活动性肝炎组的血小板四项指标水平明显优于重型肝炎和肝炎肝硬化组患者,差异具有统计学意义(P<0.05);观察组中,PLT和PCT水平与免疫球蛋白水平、门脉高压以及出血呈负相关,PDW和MPV水平与免疫球蛋白水平、门脉高压以及出血呈正相关,且差异具有统计学意义(P<0.05)。结论通过血小板四项指标水平能有效判定病毒性肝炎患者的病情,对该患者的诊治以及预后具有重要意义。
Objective To investigate the clinical significance of detecting four indexes of platelet in diagnosis and treatment of viral hepatitis. Methods A total of 180 patients with viral hepatitis treated in Quzhou People’s Hospital from May 2012 to August 2014 were selected as the observation group and divided into three groups according to their condition: acute hepatitis group (n = 45), chronic active Hepatitis group 40 cases, severe hepatitis group 51 cases, hepatitis cirrhosis group 44 cases, another select the same period of 80 healthy subjects as a control group. The PLT, PCT, PDW and MPV of each group were detected and recorded. Statistical analysis was performed and the correlations with immunoglobulin Level, portal hypertension, and bleeding disorders. Results The level of platelets in the control group was significantly better than that in the observation group (P <0.05). The levels of platelets in acute hepatitis and chronic active hepatitis group were significantly better than those in severe hepatitis and hepatitis cirrhosis group (P <0.05). In the observation group, PLT and PCT levels were negatively correlated with immunoglobulin levels, portal hypertension and hemorrhage. The levels of PDW and MPV were positively correlated with the levels of immunoglobulin, portal hypertension and Bleeding was positively correlated, and the difference was statistically significant (P <0.05). Conclusion It is of great importance to diagnose and prognose the patients through the evaluation of four indexes of platelets to effectively determine the condition of patients with viral hepatitis.