防御素属于阳离子抗菌肽家族，具有广泛的抗微生物活性、细胞毒性和免疫趋化作用，在先天免疫系统中起着重要作用。近些年，随着防御素抗病毒的研究更加深入，越来越多的证据表明防御素不仅能直接灭活病毒和阻止病毒吸附、穿入及细胞内信号转导抑制病毒复制，还可以间接通过介导免疫反应发挥抗病毒作用。这种天然的抗菌肽具有抗包膜病毒和无包膜病毒的活性。“,”Defensins belong to the cationic antimicrobial peptide family and have extensive antimicrobial activity,cell toxicity and immune chemotaxis,playing an important role in the innate immune system.In recent years,with the deepening of the study on antiviral defense,more and more evidence showed that defensins not only can directly inactivate virus and prevent virus adsorption,penetration and intracellular sig-nal transduction and inhibit virus replication,they also play an indirect antiviral role by mediating immune response.The natural antibacterial peptides have the antibacterial activity against both enveloped and non-enveloped viruses.