烯胺(enamines)是指具有结构的一类化合物的总称,但是习惯上所谓烯胺往往是指α,β-不饱和三级胺。烯胺这类化合物虽然早被知道,然而,被化学工作者所重视还只是近十年来的事。在1954年Stork利用烯胺作为中间体提出了一类羰基化合物的烷基化和酰基化的新合成方法。这类合成方法不需要碱性催化剂,可以免除碱催化的烷基化和酰基化反应中由于碱的存在而引起的许多困难,如自缩合反应、Michael反应、再烷基化等副反应。近年来利用这一反应合成了许多难以制得的化合物,提供了 Enamines refer to the general term for a class of compounds that have the structure, but the term enamine is conventionally used to refer to alpha, beta-unsaturated tertiary amines. Although such compounds as enamine have long been known, however, it is only for the last decade that chemists value it. In 1954 Stork used enamine as an intermediate to propose a new synthetic method for the alkylation and acylation of a class of carbonyl compounds. This kind of synthesis method does not need alkaline catalyst, which can avoid many difficulties caused by the presence of alkali in base-catalyzed alkylation and acylation reactions, such as self-condensation reaction, Michael reaction, realkylation and other side reactions. In recent years, the use of this reaction synthesis of many difficult to prepare compounds provided