目的:研究褪黑激素对受损伤脑神经元的保护作用和对脑缺血后bcl-2,bax表达的影响,方法:用大鼠大脑中动脉梗死再灌注脑缺血模型,以脑梗死面积和存活细胞百分率作为脑损伤指标,用免疫组化的方法分析bcl-2,bax的表达,结果:缺血再灌后24 h褪黑激素呈剂量依赖性的减少脑梗死面积,减少缺血周边区细胞死亡,并显著增加该区bcl-2的表达,而对bar的表达则无明显影响,结论:褪黑激素具有明显减少缺血性神经细胞死亡的作用,该作用机制可能与神经细胞上bcl-2的表达有关。 Objective: To study the protective effect of melatonin on injured neurons and the effect of bcl-2 and bax on the expression of bcl-2 and bax after cerebral ischemia.Methods: The cerebral infarction model And surviving cells as indicators of brain injury, immunohistochemical analysis of bcl-2, bax expression results: 24 h after ischemia-reperfusion melatonin in a dose-dependent manner to reduce the area of ​​cerebral infarction and reduce ischemic peripheral Cell death and significantly increase the expression of bcl-2 in this area, but had no significant effect on the expression of bar.Conclusion: Melatonin has the effect of significantly reducing the death of ischemic neuronal cells, which may be related to the neuronal cell bcl-2 expression.