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羟自由基（·ＯＨ）生成液０．０５ｍＬ·ｋｇ１ｉｖ使麻醉大鼠的左心室收缩期峰值压。平均动脉压。左心室收缩期峰值压与心率乘积。左室等容收缩期压力最大上升速率和左室等容舒张期压力最大下降速率明显下降，而左室舒张末期压力和血浆丙二醛（ＭＤＡ）含量显著升高．给·ＯＨ前５ｍｉｎｉｖ尼卡地平（Ｎｉｃ）０．５２μｇ·ｋｇ－１可明显而持久地降低ＭＤＡ含量，但对血流动力学及心肌收缩性能指标仅有短暂改善作用．给·ＯＨ后即ｉｖ多巴胺（ＤＡ）０．２μｇ·ｋｇ－１·ｍｉｎ１对上述功能指标的改善明显而持久．但对·ＯＨｉｖ后即刻出现的ＭＤＡ升高无明显对抗效应．当Ｎｉｃ与ＤＡ按前述方法合用后不仅血浆ＭＤＡ含量趋于正常．而且对功能指标的改善还较两药单用显著．稳定和持久．提示Ｎｉｃ与ＯＡ合用对·ＯＨ所致血流动力学及心肌收缩性能异常有协同保护效应．
Hydroxyl radical (· OH) production solution 0.05mL · kg1iv anesthetized rats left ventricular systolic peak pressure. Mean arterial pressure. Left ventricular systolic peak pressure and heart rate product. The maximum rate of left ventricular isokinetic systolic pressure and the maximum rate of left ventricular diastolic pressure decreased significantly, while the left ventricular end diastolic pressure and plasma MDA content increased significantly. In the first 5 min of · OH, nicardipine (Nic) 0.52 μg · kg-1 significantly and persistently decreased MDA content, but only transiently improved the hemodynamics and myocardial contractility. Give · OH after iv dopamine (DA) 0.2μg · kg-1 · min1 of the above-mentioned functional indicators of significant and lasting improvement. However, there was no obvious antagonistic effect on the increase of MDA immediately after · OHiv. When Nic and DA were combined as described above, not only plasma levels of MDA tended to be normal. And the improvement of functional indicators than the two drugs alone significantly. Stable and lasting. It is suggested that the combined use of Nic and OA has a synergistic protective effect on the hemodynamic and myocardial contractility induced by · OH.