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目的:探讨蛇床子素对脑出血大鼠脑损伤的保护作用,并研究其相关因子的作用机制。方法:将75只Wistar大鼠,随机分为假手术组、模型对照组、给药治疗组,共计3组,每组25只。在4 h、16 h、1 d、3 d、5 d分别检测脑组织SOD含量及血清IL-8含量变化。结果:给药治疗组在蛇床子素的作用下5个时间点检测血清IL-8含量相比模型对照组下调而SOD含量相对上调,并减轻脑水肿的程度,有显著差异性(P<0.01)。结论:蛇床子素能够提高脑出血大鼠脑组织中SOD含量并使血清IL-8含量减少,有保护水肿的脑组织作用。
Objective: To investigate the protective effect of osthole on brain injury induced by intracerebral hemorrhage (ICH) in rats and its mechanism of action. Methods: Seventy-five Wistar rats were randomly divided into sham-operated group, model control group and drug-treated group. There were 3 groups in total, 25 in each group. At 4 h, 16 h, 1 d, 3 d and 5 d, the content of SOD and the content of IL-8 in serum were detected. Results: Compared with the model control group, the level of IL-8 in the serum of the treatment group was significantly decreased (P <0.01) and the level of SOD was increased ). Conclusion: Osthole can enhance the content of SOD in the brain tissue of rats with ICH and decrease the content of IL-8 in serum and protect the edema of brain.