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蠕虫感染引起的免疫反应主要是速发型过敏反应。实验动物及人感染蠕虫后表现出IgE抗体增高,血循环中嗜酸粒细胞、嗜硷性细胞增多和组织内大量嗜酸粒细胞、嗜硷性细胞及肥大细胞浸润。这些为速发型过敏反应的基本特征。由于推测速发型超敏反应在抗蠕虫感染中起作用,本文作者着重研究了预防接种照射尾蚴小鼠抗曼氏血吸虫攻击感染的能力与IgE抗体水平和肥大细胞脱颗粒作用之间的关系。 C57BL/6小鼠,用500条照射尾蚴进行预防接种,而后取血清,用固相放射免疫法测定抗可溶性成虫抗原(SWAP)及尾蚴抗原
The immune response caused by helminth infection is mainly an immediate allergic reaction. Experimental animals and humans infected with worms showed increased IgE antibodies, blood circulation eosinophils, basophils increased and a large number of tissue eosinophils, basophils and mast cell infiltration. These are the basic features of immediate hypersensitivity reactions. Since it is hypothesized that immediate-hypersensitivity plays a role in anthelmintic infection, the authors focus on the relationship between the ability to prevent infection with Schistosoma mansoni inoculated with vaccinated cercariae and IgE antibody levels and mast cell degranulation. C57BL / 6 mice were immunized with 500 irradiated cercariae and then serum was collected. Anti-soluble adult worm antigen (SWAP) and cercaria antigens were determined by solid-phase radioimmunoassay