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目的分析低钠血症与慢性心力衰竭(CHF)的相关性。方法 86例CHF患者,其中伴低钠血症者36例(低血钠组),血钠正常者50例(正常血钠组),低血钠组除常规治疗外加用高渗盐补钠,分析血钠与脑钠肽(BNP)及左室射血分数(LVEF)的关系,及补钠治疗对心功能的影响。结果低血钠组患者血浆BNP水平(1522.9±425.7)ng/L较正常血钠组(893.7±302.9)ng/L明显增高(P<0.05);相关性分析显示,血钠越低,BNP水平越高,血钠水平与BNP呈现负相关(r=-0.627),两组LVEF比较差异无统计学意义(P>0.05);低血钠组患者综合治疗后心功能明显改善,心功能Ⅲ级患者总有效率为100.0%,心功能Ⅳ级患者为87.5%。结论低钠血症可能促进BNP分泌增加,低钠提示心力衰竭恶化,纠正低钠血症可明显改善心功能。
Objective To analyze the correlation between hyponatremia and chronic heart failure (CHF). Methods Totally 86 CHF patients, including 36 cases with hyponatremia (hyponatremia group), 50 cases with normal serum sodium (normal serum sodium group) and the other with hyponatremia group were treated with hypertonic saline, Analysis of the relationship between serum sodium and brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF), and sodium supplementation on cardiac function. Results Compared with normal sodium group (893.7 ± 302.9) ng / L, the level of plasma BNP (1522.9 ± 425.7) ng / L in hyponatremia group was significantly higher (P <0.05); correlation analysis showed that the lower the serum sodium level, the lower the BNP level The higher the level of serum sodium was negatively correlated with BNP (r = -0.627), there was no significant difference in LVEF between the two groups (P> 0.05). The cardiac function in patients with hyponatremia group was significantly improved after treatment, The total effective rate was 100.0% and 87.5% of patients with grade IV heart function. Conclusions Hyponatremia may promote the increase of BNP secretion. Hyponatremia indicates the worsening of heart failure. Correcting hyponatremia may improve cardiac function.