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Imipenem N-亚氨代甲基硫霉素(简称Ⅰ)是碳青霉烯类(Carbapenems)第一个应用于临床的硫霉素(Thienamydn)衍生物,在现有β-内酰胺抗菌剂中具有最广的抗菌谱,与其他β-内酰胺抗生素相比,Ⅰ与目前应用的广谱青霉素以及第三代头孢菌素均无交叉耐药性。Ⅰ主要与青霉素结合蛋白(PBPs)中的PBP-1和PBP-2结合,尤与PBP-2的结合可导致细菌形态产生变化,而且由于Ⅰ对绿脓杆菌、金黄色葡萄球菌及大
Imipenem N-Methylthiomycin (referred to as Ⅰ) is the first carbapenem (Carbapenems) the first clinical application of thienamycin (Thienamydn) derivatives, existing β-lactam antibacterial agents With the most extensive antibacterial spectrum, compared with other β-lactam antibiotics, Ⅰ and the current broad-spectrum penicillin and third-generation cephalosporins are not cross-resistant. Ⅰ mainly binds to PBP-1 and PBP-2 in penicillin-binding proteins (PBPs). In particular, the binding of PBP-2 to PBP-2 leads to the change of bacterial morphology. Moreover, due to the combination of Ⅰ against Pseudomonas aeruginosa, Staphylococcus aureus,