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目的:探讨肾细胞癌(renal cell carcinoma tissue,RCC)组织中Annexin-1的表达及意义。方法:应用免疫组织化学方法检测56例肾癌组织、20例癌旁组织和16例肾细胞组织中Annexin-1的表达情况。结果:肾癌组织、癌旁组织和肾细胞组织中Annexin-1的阳性表达率分别为21.43%(12/56)、35%(7/20)和81.25%(13/16)。结论:Annexin-1在肾癌组织、癌旁组织中的表达较肾细胞组织中的表达显著降低,检测Annexin-1有望为肾细胞癌的早期诊治提供理论依据。
Objective: To investigate the expression of Annexin-1 in renal cell carcinoma tissue (RCC) and its significance. Methods: Immunohistochemistry was used to detect the expression of Annexin-1 in 56 cases of renal cell carcinoma, 20 cases of paracancerous tissues and 16 cases of renal cell carcinoma. Results: The positive rates of Annexin-1 in renal cell carcinoma tissues, paracancerous tissues and renal cell tissues were 21.43% (12/56), 35% (7/20) and 81.25% (13/16), respectively. CONCLUSION: The expression of Annexin-1 in renal cell carcinoma and paracancerous tissues is significantly lower than that in renal cells. Detecting Annexin-1 is expected to provide a theoretical basis for the early diagnosis and treatment of renal cell carcinoma.