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North JP...//Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognosticinformation in primary melanoma.Am J Surg Pathol,2011,35(8):1146-1150.几十年来,黑色素瘤发病率一直稳步上升,而死亡率持平。这种发病率与死亡率不一致的现象与甲状腺、乳腺和前列腺恶性肿瘤诊断上的变化有关。辅助检查,如荧光原位杂交(FISH)已被用来区分黑色素瘤和黑素细胞痣。多色FISH在辨别这两者上的敏感度为86.7%,特异性为95.4%。为了评价FISH区分伴有转移性或致死潜能的黑色素瘤与惰性病程者的能力,
North JP ... // Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma. Am J Surg Pathol, 2011, 35 (8): 1146-1150. For decades, the incidence of melanoma Has steadily risen, while the mortality rate is flat. This discrepancy between morbidity and mortality is associated with the diagnosis of thyroid, breast and prostate malignancies. Auxiliary tests, such as fluorescence in situ hybridization (FISH), have been used to distinguish melanomas from melanocytic nevi. The sensitivity of multicolor FISH in discriminating the two was 86.7% with a specificity of 95.4%. In order to evaluate the ability of FISH to distinguish melanoma associated with metastatic or lethal potential from those with an inactive course of disease,