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目的 :探讨肿瘤特异性生长因子(TSGF)与癌胚抗原(CEA)在消化道恶性肿瘤患者血清中的表达水平及其临床意义。方法 :使用生化比色法检测TSGF、放射免疫法检测CEA,观察两者在55例消化道肿瘤中的表达水平,并与50例健康体检者的血清表达水平进行对比,研究分析TSGF与CEA联合检测的阳性检出率与单独检测的阳性检查率的差异。结果 :消化道肿瘤患者血清TSGF(71.39±16.57)和CEA(2.15±2.03)明显高于正常对照组,P<0.05,差异有统计学意义;TSGF、CEA各自单独及联合检测的阳性率分别为69.47%,53.26%,80.10%。结论 :TSGF、CEA可用于消化道恶性肿瘤的检测,联合检测可提高消化道恶性肿瘤的阳性检出率。
Objective: To investigate the expression of tumor-specific growth factor (TSGF) and carcinoembryonic antigen (CEA) in the serum of patients with gastrointestinal cancer and its clinical significance. Methods: The biochemical colorimetric assay was used to detect TSGF. Radioimmunoassay was used to detect CEA. The expression of CEA was detected in 55 cases of gastrointestinal tumors. The serum levels of CEGF were compared with those of 50 healthy controls. The difference between the positive detection rate of the test and the positive test rate of the single test. Results: Serum TSGF (71.39 ± 16.57) and CEA (2.15 ± 2.03) in patients with gastrointestinal cancer were significantly higher than those in normal control group (P <0.05), and the difference was statistically significant. The positive rates of TSGF and CEA separately and in combination were 69.47%, 53.26%, 80.10%. Conclusion: TSGF and CEA can be used for the detection of gastrointestinal malignancies. Combined detection can improve the positive detection rate of gastrointestinal malignancies.