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环形肉芽肿(GA)是以非干酪样的皮肤肉芽肿伴有结缔组织改变为特征。成人T细胞白血病/淋巴瘤(ATL)由人类T细胞白血病病毒(HTLV)-1引起,是一种致命的淋巴细胞增生性疾病,以存在大量扭曲畸形核的白血病细胞为特征。ATL常伴有多系统损害,包括肝、脾、淋巴结肿大、中枢神经系统损害及皮肤损害,皮肤活检发现特异性的皮肤表现有助于对ATL进行鉴别。目前,日本St Marianna大学医学院Kawakami T等首次报道了一例以GA样皮肤损害为首发表现的ATL病例。
Circumferential granulomas (GA) are characterized by non-caseous skin granulomas with connective tissue changes. Adult T-cell leukemia / lymphoma (ATL), caused by human T-cell leukemia virus (HTLV) -1, is a fatal lymphoproliferative disease characterized by the presence of a large number of leukemic cells that distort the nucleus deformity. ATL is often associated with multiple system impairments, including liver, spleen, enlarged lymph nodes, central nervous system damage, and skin lesions. Skin biopsies that identify specific skin manifestations help identify ATL. At present, Japan’s St Marianna University School of Medicine Kawakami T first reported an example of GA-like skin lesions as the first episode of ATL cases.