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目的和方法 :本实验在大鼠主动脉球囊剥脱模型上 ,观察血浆和主动脉组织C -型利钠利尿肽(CNP)的动态变化及外源性CNP对大鼠球囊损伤后内膜生成的影响 ,以探讨CNP在再狭窄中的作用。结果 :发现大鼠球囊损伤后血浆CNP的浓度升高 ,内膜剥脱后第 3d、10d、2 1d ,血浆CNP水平分别增高 80 7% (P <0 0 1) ,43 5 % (P <0 0 5 )和 2 7 5 % (P <0 0 5 ) ,而主动脉组织CNP含量在损伤后第 3d下降 46 6 % (P <0 0 5 ) ,第10d ,2 1d和 2 8dCNP含量分别增加 2 8倍 (P <0 0 1)、1 6倍 (P <0 0 5 )和 0 82倍 (P <0 0 5 )。外源性CNP显著抑制球囊损伤后第 7d和 2 1d新生内膜的形成 ,内膜 /中膜比值分别降低 2 2 % (P <0 0 5 )和 2 0 % (P <0 0 5 )。结论 :CNP参与血管球囊损伤后的修复过程 ,外源性CNP可抑制内膜增厚。
PURPOSE AND METHODS: In this study, we observed the dynamic changes of C - type natriuretic peptide (CNP) in plasma and aortic tissue of rat aorta and the effect of exogenous CNP on the intima To investigate the role of CNP in restenosis. Results: The plasma concentration of CNP increased after balloon injury in rats. The levels of plasma CNP increased by 80.7% (P <0.01) and 43.5% (P <0.01) on 3d, 10d, (P <0.05), while the content of CNP in the aortic tissue decreased 466% (P <0.05) on the 3rd day after injury, and the content of CNP in the aortic tissue at the 10th, 21st and 28th day respectively Increased 28 times (P <0.01), 16 times (P <0 05) and 0 82 times (P <0 05). Exogenous CNP significantly inhibited neointimal hyperplasia on the 7th and 21st day after balloon injury. The intima / media ratio decreased by 22% (P <0.05) and 20% (P <0 05), respectively . CONCLUSION: CNP is involved in the repair process after vascular balloon injury. Exogenous CNP can inhibit intimal thickening.