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目的了解河南省≤15岁儿童吉兰-巴雷综合征(GBS)流行病学特征,为制定其防控策略提供科学依据。方法对河南省2004—2012年急性弛缓性麻痹病例监测系统报告的1 291例≤15岁GBS病例进行描述性分析。结果河南省≤15岁儿童GBS病例主要表现为散发,年平均发病率为0.75/10万,其中济源、洛阳、三门峡、濮阳、商丘发病率居前5位,分别为1.40/10万、1.09/10万、0.96/10万、0.95/10万、0.92/10万;发病高峰多出现于每年6—8月,1~4岁组发病率较高,男性发病率高于女性,男女性别比为1.85∶1;186例GBS病例分离出肠道病毒,肠道病毒分离率为14.41%,26.10%的病例麻痹60 d后有残留麻痹。结论河南省≤15岁儿童GBS病例以小年龄组为主,多发生于夏秋季,男性发病率高于女性,儿童GBS病例残留麻痹率较高,应及时采取措施降低致残率。
Objective To understand the epidemiological characteristics of Guillain - Barre syndrome (GBS) in children ≤15 years old in Henan Province, and to provide a scientific basis for formulating its prevention and control strategies. Methods A total of 1 291 cases of GBS ≤15 years old reported by Henan Acute Flaccid Paralysis Surveillance System from 2004 to 2012 were analyzed descriptively. Results The incidence of GBS in children ≤15 years old was mainly distributed in Henan Province with the annual average incidence of 0.75 / 100,000. Among them, the incidence of GBS in Jiyuan, Luoyang, Sanmenxia, Puyang and Shangqiu was the top five, with 1.40 / 100000 and 1.09 / 10, 0.96 / 100000, 0.95 / 100000, 0.92 / 100000; peak incidence occurred in June-August each year, 1 to 4-year-old group had a higher incidence of male morbidity than women, male to female sex ratio 1.85:1; Enterovirus was isolated from 186 cases of GBS, the rate of enterovirus isolation was 14.41%, and paralysis was observed after 60 days in 26.10% of cases. Conclusions The cases of GBS in children ≤15 years old in Henan Province are mainly in the younger age group, which occur mostly in summer and autumn. The incidence of GBS in children is higher than that in women. The residual paralysis rate of children with GBS is higher. Measures should be taken in time to reduce the morbidity.