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目的比较地特胰岛素(Det)与甘精胰岛素(Gla)联合速效胰岛素治疗T2DM疗效。方法将血糖控制不佳T2DM患者70例分为Det组和Gla组,每组35例,治疗24周,比较两组治疗前后HbAl c、FPG、晚餐前血糖(PDPG)、胰岛素剂量、体重增加及低血糖发生情况。结果经过24周治疗,两组HbA1c、FPG均下降(P<0.01),组间比较差异无统计学意义。两组PDPG均下降(P<0.01),组间比较差异有统计学意义(P<0.01)。Gla组胰岛素剂量较Det组低,体重增加较Det组高(P<0.05)。Det、Gla组低血糖事件发生风险分别为8.69、8.92事件/(患者·年)。结论 1次/d Det联合速效胰岛素是治疗血糖控制不佳T2DM患者的有效方案之一。
Objective To compare the efficacy of Det and insulin combined with Gla insulin in the treatment of T2DM. Methods Seventy patients with poor blood glucose control (T2DM) were divided into Det group and Gla group, 35 patients in each group for 24 weeks. HbA1c, FPG, PDPG, insulin dosage, Hypoglycemia occurs. Results After 24 weeks of treatment, HbA1c and FPG in both groups decreased (P <0.01), and there was no significant difference between the two groups. PDPG in both groups decreased (P <0.01), the difference between the two groups was statistically significant (P <0.01). The insulin dose in Gla group was lower than that in Det group and higher than that in Det group (P <0.05). The risk of hypoglycaemia in Det and Gla group were 8.69 and 8.92 respectively / (patient · year). Conclusions 1 d / d Det combined with rapid-acting insulin is one of the effective treatments for patients with poorly controlled blood glucose.