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核酸是生命的物质基础,是遗传信息的传递者,是细胞分化、分裂的主要控制者。大量证据表明,白血病的病因、诊断和治疗与核酸的关系极为密切。本文将主要介绍核酸代谢的异常与白血病病因的关系、核酸代谢酶在白血病诊断和鉴别上的应用以及核酸或利用核酸代谢途径在白血病治疗中的意义等。 (一)核酸与肿瘤病因无论化学致癌、物理致癌或病毒致癌,从分子生物学的角度来看,导致细胞癌变的机理,不外乎两种基本的观点:(1)基因表现的调控失常即调控机构失
Nucleic acid is the material basis of life, is the transmitter of genetic information, and is the main controller of cell differentiation and division. A lot of evidence shows that the etiology, diagnosis and treatment of leukemia are closely related to nucleic acid. This article will mainly introduce the relationship between the abnormality of nucleic acid metabolism and the etiology of leukemia, the application of nucleic acid metabolism enzyme in the diagnosis and identification of leukemia, and the significance of nucleic acid or the use of nucleic acid metabolism pathway in the treatment of leukemia. (1) Nucleic Acid and Tumor Causes Regardless of chemical carcinogenesis, physical carcinogenesis, or viral carcinogenesis, from the perspective of molecular biology, the mechanism leading to cell carcinogenesis is nothing more than two basic viewpoints: (1) The abnormal regulation of gene expression Loss of regulatory agency