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目的 采用高能聚焦超声 (highintensityfocusedultrasound ,HIFU)技术治疗中晚期胰腺癌 ,观察HIFU对胰腺肿瘤的杀伤效应及缓解胰腺癌疼痛的有效性 ,并探讨其对机体免疫功能的影响。方法 采用HIFU分次完全覆盖疗法 ,对 15例晚期胰腺癌患者进行治疗 ,通过治疗前后临床症状、病灶体积及回声变化、血清CA19 9、CA2 4 2、CD3+、CD4 +、CD4 +/CD8+值和NK细胞活性等指标观察HIFU的治疗效果。结果 治疗后胰腺癌患者临床症状减轻 ,疼痛症状明显缓解 ,CA19 9、CA2 4 2水平下降 ,病灶B超回声增强 ,无严重并发症出现 ,饮食、睡眠及精神状态均有明显改善 ,生存质量提高。CD3+、CD4 +细胞数量及CD4 +/CD8+值有不同程度升高 ,NK细胞活性显著增强 (P <0 0 5 )。结论 HIFU治疗晚期胰腺癌是安全和可行的 ,可导致肿瘤坏死 ,缓解疼痛症状 ,增强机体的细胞免疫功能 ,该技术的应用将为临床非侵入性治疗晚期胰腺癌提供一个新的治疗手段
Objective To investigate the effect of HIFU on pancreatic cancer and its efficacy in relieving pancreatic cancer by using high intensity focused ultrasound (HIFU) in the treatment of advanced pancreatic cancer. Methods Fifteen patients with advanced pancreatic cancer were treated with HIFU fractional complete coverage therapy. The clinical symptoms, lesion volume, echogenicity, serum CA19 9, CA 2 4 2, CD 3 +, CD4 +, CD4 + / CD8 + NK cell activity and other indicators observed HIFU treatment. Results After treatment, the clinical symptoms of patients with pancreatic cancer were relieved and the pain symptoms were relieved. The levels of CA19 9 and CA2 4 2 were decreased, the echogenicity of the lesions was enhanced, and no serious complications occurred. The diet, sleep and mental status were significantly improved and the quality of life was improved . The number of CD3 +, CD4 + cells and CD4 + / CD8 + increased to some extent, NK cell activity increased significantly (P <0.05). Conclusion The treatment of advanced pancreatic cancer with HIFU is safe and feasible, which can lead to tumor necrosis, relieve the pain symptoms and enhance cellular immune function. The application of this technique will provide a new therapeutic method for the noninvasive treatment of advanced pancreatic cancer