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目的 :研究单硝酸异山梨酯片 ( ISMN,欣乐 )加西沙必利预防食管静脉曲张破裂出血 ( EVB)再发生的疗效。方法 :5 5例患者分为观察组 3 0例 ,服 ISMN加西沙必利 ;对照组 2 5例 ,给予软食、保肝及一般的对症治疗。两组均维持治疗 1年。结果 :观察组服药期间 EV B复发率 6.7% ,对照组 3 6.0 % ( P <0 .0 1)。停药后 1年内 EVB复发率观察组 14 .3 % ,对照组5 0 .0 % ( P <0 .0 5 )。结论 :ISMN加西沙必利预防 EVB再发生疗效显著 ,可作为首选方法之一。
Objective: To study the effect of isosorbide mononitrate tablets (ISMN, Xinle) plus cisapride in preventing recurrence of esophageal variceal bleeding (EVB). Methods: Fifty-five patients were divided into observation group (30 cases) and ISMN plus cisapride (25 cases). The control group was given soft diet, liver protection and general symptomatic treatment. Two groups were treated for 1 year. Results: The recurrence rate of EV B was 6.7% in the observation group and 3 6.0% in the control group (P <0.01). The relapse rate of EVB within one year after discontinuation was 14.3% in the observation group and 50.0% in the control group (P <0.05). CONCLUSIONS: ISMN plus cisapride has a significant effect in preventing recurrence of EVB and may be one of the preferred methods.