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本文从中医分型观察了乙型慢性迁延性肝炎中医各型与染色体损伤和肝功能的关系。结果表明:肝郁脾虚型、湿热型及湿热未净型患者染色体总畸变率及姊妹染色单体互换频率均明显高于健康人;其中肝郁脾虚型患者姊妹染色单体互换频率较其他二型为高。说明乙型慢性迁延性肝炎患者均存在较明显的染色体损伤情况;而不同中医分型患者,由于机体免疫功能不同,染色体损伤程度和肝功能的改变各异。提示机体反应性对乙型肝炎患者染色体的损伤程度有一定的影响。
This article has observed the relationship between traditional Chinese medicine types of chronic persistent hepatitis B and chromosome damage and liver function. The results showed that the total chromosome aberration rate and sister chromatid exchange frequency were significantly higher in patients with liver depression, spleen deficiency, damp-heat type and non-heat-heat type than in healthy individuals; among them, sister chromatid exchange frequency was higher than that of other patients with liver depression and spleen deficiency type. The second type is high. It shows that there are obvious chromosomal damages in patients with chronic persistent hepatitis B, while patients with different types of traditional Chinese medicine have different degrees of chromosome damage and liver function due to different immune functions. It is suggested that the body’s reactivity has a certain influence on the extent of chromosome damage in patients with hepatitis B.