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【目的】以壳聚糖(CS)为壁材,杀菌农药戊唑醇(TBA)为芯材,采用乳化喷雾干燥法制备出载戊唑醇/壳聚糖(TBA/CS)微胶囊制剂。【方法】通过扫描电子显微镜探讨了乳液组成(水油比)和喷雾干燥条件对TBA/CS微胶囊结构和形貌的影响,并通过模拟释放实验研究了TBA/CS微胶囊的缓释性能。【结果】当CS溶液质量分数为1.2%,表面活性剂质量分数为1.1%,喷雾气体压力为4 bar(400 kPa),进料速度10.5 m~3/h时,制得的TBA/CS微胶囊有规整的球形结构,且具有良好的缓释性能,对白色念珠菌具有明显的抑菌效果。【结论】乳化喷雾干燥法制备载戊唑醇/壳聚糖(TBA/CS)微胶囊的方法简单,CS溶液浓度、表面活性剂浓度、喷雾气体压力、进料速度等实验条件对制备的TBA/CS微胶囊形貌有较大的影响。
【Objective】 The preparation of tebuconazole / chitosan (TBA / CS) microcapsules was prepared by emulsion spray drying method using chitosan (CS) as the wall material and bactericidal pesticide tebuconazole (TBA) as the core material. 【Method】 The effects of emulsion composition (water-oil ratio) and spray-drying conditions on the structure and morphology of TBA / CS microcapsules were investigated by scanning electron microscopy. The sustained-release properties of TBA / CS microcapsules were studied by simulated release experiments. 【Result】 The TBA / CS microspheres prepared when the concentration of CS solution was 1.2%, the surfactant concentration was 1.1%, the pressure of spray gas was 4 bar (400 kPa) and the feed rate was 10.5 m ~ 3 / h Capsule has a regular spherical structure, and has good sustained-release properties, Candida albicans has obvious inhibitory effect. 【Conclusion】 The method of emulsified spray drying for preparing tebuconazole / chitosan (TBA / CS) microcapsules is simple, the concentration of CS solution, surfactant concentration, spray gas pressure, feed rate and other experimental conditions on the preparation of TBA / CS microcapsule morphology has a greater impact.