延胡索乙素2,3-和9-的三个甲氧基及四氢小檗碱的9-甲氧基分别换以乙氧基及各种酰氧基,制得11个类似物.又分别合成了2,3-二羟基与2,3-次甲二氧基-9,10-二甲氧基小蘖因的氯丁烷与丁撑二溴季铵盐.合成的化合物经药理试验表明其中乙氧基及酰氧基小蘖因虽保留延胡索乙素的镇痛和镇静作用,但它们的作用强度大都减弱. The three methoxy groups of tetrahydropalmatine 2,3- and 9- and the 9-methoxy group of tetrahydroberberine were replaced by ethoxy groups and various acyloxy groups respectively to prepare 11 analogues Synthesis of 2,3-dihydroxy and 2,3-dimethoxy-9,10-dimethoxy small tiller factor butane chloride and butadiene dibromium quaternary ammonium compounds were synthesized by the pharmacological test showed Among them, ethoxy and acyloxy small tiller although they retain the analgesic and sedative effects of tetrahydropalmatine, but their intensity of action is mostly weakened.