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血管内皮细胞（VEC）损伤是创伤的重要组成部份，其机理尚待深入研究。近年来，国外有关循环内皮细胞（CEC）的研究为在临床和体内探讨VEC的变化提供了重要手段。本研究旨在从基础研究和临床研究两方面探讨VEC损伤机理、VEC损伤后CEC的变化规律和病理生理改变，以及能促进临床研究VEC损伤的实验方法。
Vascular endothelial cell (VEC) injury is an important part of trauma, the mechanism remains to be further studied. In recent years, foreign research on circulating endothelial cells (CEC) provides an important means to explore the changes of VEC in clinic and in vivo. The purpose of this study is to explore the mechanisms of VEC injury, the changes of CEC and pathophysiological changes after VEC injury, as well as the experimental methods that can promote the clinical research of VEC injury from the aspects of basic research and clinical research.