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目的 :观察胎盘免疫调节因子 (PIF)对恶性肿瘤病人外周血 T淋巴细胞亚群的影响。方法 :利用 PIF治疗妇科恶性肿瘤 6 3例 ,肺癌 36例 ,检测并比较 PIF治疗前后病人外周血 T淋巴细胞亚群指标。结果 :妇科恶性肿瘤病人及肺癌病人经 PIF治疗后 ,治疗组病人的外周血 CD3、CD4、 CD4/ CD8比值明显增高 ,而对照组的这些指标均有所降低。结论 :提示PIF可提高妇科恶性肿瘤病人及肺癌病人的细胞免疫功能。
Objectives: To observe the effect of placental immunoregulatory factor (PIF) on peripheral blood T lymphocyte subsets in patients with malignant tumors. METHODS: PIF was used to treat 63 cases of gynecologic malignancies and 36 cases of lung cancer. The peripheral blood T-lymphocyte subsets before and after PIF treatment were detected and compared. Results : After treatment with PIF in patients with gynecologic malignancy and lung cancer, the ratios of CD3, CD4, and CD4/CD8 in peripheral blood of the patients in the treatment group were significantly higher, while those in the control group were all decreased. Conclusion : It is suggested that PIF can improve the cellular immune function of patients with gynecologic malignancy and lung cancer.