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目的 探讨血清中肝癌特异性GGT同工酶区带 (HSB)、铁蛋白 (SFn)、肿瘤坏死因子 α(TNF α)和脂质结合唾液酸 (LSA)浓度改变在肝癌诊断与鉴别中的临床价值。方法 分别定量检测了肝癌、慢性肝病和肝外肿瘤患者血清HSB、SFn、TNF α和LSA浓度 ,并比较分析了它们的临床意义。结果 肝癌组血清HSB浓度经导管动脉栓塞 (TAE)前明显异常 ,同时也高于慢性肝炎、肝硬化和肝外肿瘤病人 (P <0 0 0 1) ;SFn、LSA和TNF α水平在肝癌组明显高于慢性肝病患者 ,但与其他肿瘤无鉴别价值 ;肝癌组HSB、SFn、LSA和TNF α的阳性率分别为 91 1%、5 3 3 %、67 8%和 86 7%。结论 资料证明HSB定量和定性检测均优于SFn、LSA和TNF α浓度分析 ,但多项指标联合分析有助于肝癌的诊断与鉴别
Objective To investigate the changes of serum specific GGT isoenzyme bands (HSB), ferritin (SFn), tumor necrosis factor α (TNFα) and lipid-bound sialic acid (LSA) in the diagnosis and differential diagnosis of hepatocellular carcinoma value. Methods The concentrations of serum HSB, SFn, TNFα and LSA in patients with liver cancer, chronic liver disease and extrahepatic tumor were detected quantitatively. Their clinical significance was compared and analyzed. Results The levels of serum HSB in patients with hepatocellular carcinoma were significantly abnormal before TAE and also higher than those in patients with chronic hepatitis, cirrhosis and extrahepatic tumors (P <0.01). The levels of SFn, LSA and TNFα in HCC The positive rates of HSB, SFn, LSA and TNFα in liver cancer group were 91 1%, 53 3%, 67 8% and 86 7%, respectively, which were significantly higher than those in patients with chronic liver disease. Conclusions The data prove that the quantitative and qualitative detection of HSB are better than the analysis of SFn, LSA and TNFα concentration, but the combination of multiple indicators is helpful for the diagnosis and differential diagnosis of liver cancer