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慢通道钙离子拮抗剂现已广泛用于治疗冠状动脉痉挛及典型心绞痛.尽管近年来关于此类药物的资料已有很多,但仍有一系列问题未得到解决.为此,本文研究硝苯吡啶单独及与β-肾上腺素能阻滞剂合用时对左心室大小、血压、冠状动脉内径,周身血管阻力等的一系列作用.方法:13只健康狗,先在苯巴比妥钠麻醉下,植入测量冠状循环及心脏血流动力学各种指标所需要的测量计,待动物恢复后,在完全清醒的情况下,连续测定对照期及静脉注射硝苯吡啶20微克/公斤后一小时的左心室压,左室舒张期压/舒张期直径,
Slow channel calcium antagonists are now widely used in the treatment of coronary artery spasm and typical angina.Although a lot of information on these drugs in recent years, but there are still a series of problems have not been solved.To this end, nifedipine alone And a series of effects on left ventricular size, blood pressure, coronary artery diameter, and systemic vascular resistance when combined with β-adrenergic blockers.Methods: Thirteen healthy dogs were anesthetized with phenobarbital, To measure the coronary circulation and cardiac hemodynamics required by the various indicators of measurement until the animals recovered, in the case of complete awake, continuous determination of control and intravenous nifedipine 20 micrograms / kg one hour after the left Ventricular pressure, left ventricular diastolic pressure / diastolic diameter,