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昆明山海棠(Tripterygium Hypoglau-cum(Levl.)Hutch.]属卫矛科雷公藤属植物,广泛用于治疗类风湿性关节炎。在服用过程中,发现部份男性病例出现少精子或无精于症。有人也进行过其乙醇提取物对雄性大鼠的抗生育观察。为了进一步证实昆明山海棠是否具有潜在的男性抗生育作用,我们用乙醇抽提,再经溶剂和层析方法划分为若干馏分,并用Wistar大鼠做生物活性筛选,从中检出TH_4和TH_5以58mg/kg、116mg/kg剂量,每日灌胃一次,5周以后可使受试雄鼠全部丧失生育能力。停药50天后,服药大鼠又可恢复其生育能力。对试验大鼠的心、肝、脾、肺、肾及肾上腺组织进行病理学检查,未见器质性病变。服药鼠睾
Tripterygium Hypoglau-cum (Levl.) Hutch. Is a species of the genus Phalaenopsis, which is widely used in the treatment of rheumatoid arthritis. During taking, some male cases were found to have oligospermia or no essence In addition, some people also conducted their ethanol extract of male rats antifertility observation.In order to further confirm whether Kunming Begonia has potential male anti-reproductive effects, we use ethanol extraction, and then by solvent and chromatography method is divided into Several fractions were screened by Wistar rats. The TH_4 and TH_5 were tested at 58mg / kg and 116mg / kg once daily for 5 weeks, and all the tested males were deprived of fertility. After 50 days, the rats were taken again to restore their fertility.The pathological examination of the heart, liver, spleen, lung, kidney and adrenal gland of the rats was conducted and there was no organic lesion.