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目的:探讨C IK过继免疫治疗对手术后肺癌患者免疫功能的影响。方法:采用流式细胞术检测40例肺癌患者外周血T细胞、B细胞和NK细胞表型。结果:肺癌患者CD3+、CD4+、CD4/CD8比值明显低于对照组并呈显著性差异,而CD8+细胞高于对照组(P<0.01)。经C IK治疗后CD3+、CD4+、CD3-/CD16+56+细胞和CD4/CD8比值都升高,其中CD4+、CD3-/CD16+56+细胞与治疗前比较呈显著性差异(P<0.05),而CD8+细胞与治疗前比较降低(P<0.05);CD19在治疗后稍有增高趋势,但无显著性差异。结论:C IK过继免疫治疗对肺癌患者免疫功能的恢复具有促进作用。
Objective: To investigate the effect of adoptive immunotherapy with C IK on immune function in patients with lung cancer after surgery. Methods: Flow cytometry was used to detect the phenotypes of T cells, B cells and NK cells in peripheral blood of 40 patients with lung cancer. Results: The ratio of CD3 +, CD4 + and CD4 / CD8 in patients with lung cancer was significantly lower than that in control group, while CD8 + cells were higher than those in control group (P <0.01). The ratio of CD3 +, CD4 +, CD3- / CD16 + 56 + cells and CD4 / CD8 increased after C IK treatment, of which CD4 +, CD3- / CD16 + 56 + cells were significantly different from those before treatment (P 0. 05) , While CD8 + cells decreased compared with those before treatment (P <0.05); CD19 increased slightly after treatment, but there was no significant difference. Conclusion: C IK adoptive immunotherapy can promote the recovery of immune function in patients with lung cancer.