在现代化疗早期,曾有人采用腹腔内直接应用化疗药物,并证实对控制腹水有一定效果。七十年代以来,针对腹腔内肿瘤术后存在的癌灶残留或转移,腹腔内化疗又重新引起了临床的关注,本文简要介绍腹腔内化疗的基础和临床研究方面的进展。 药物动力学 腹膜是个大的透析膜,凭籍物质的大小、电荷、脂溶性、分子量等特性, In the early days of modern therapy, it was previously used directly in the abdominal cavity to administer chemotherapeutic agents and it was confirmed that it has a certain effect on the control of ascites. Since the 1970s, intraperitoneal chemotherapy has re-emerged as a clinical concern for the residual or metastasis of post-operative intracerebral tumors. This article briefly introduces the basic and clinical research progress of intraperitoneal chemotherapy. Pharmacokinetics The peritoneum is a large dialysis membrane with properties such as size, charge, fat solubility, and molecular weight.