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[目的]探讨影响巨块型早期宫颈癌复发的危险因素。[方法]回顾性分析324例巨块型早期宫颈癌患者与复发相关的治疗和病理因素。[结果]全组复发率39.0%,5年生存率为62.5%。单因素分析显示新辅助化疗、病理分级、盆腔淋巴结转移、脉管侵犯、手术切缘癌细胞残留、深肌层癌细胞浸润、宫旁癌细胞浸润等与肿瘤复发关系密切(P<0.05)。COX多因素分析显示癌细胞分化程度低、深肌层癌细胞浸润和盆腔淋巴结转移是影响复发的主要危险因素(P<0.05)。[结论]巨块型早期宫颈癌的治疗需强调综合治疗,以减少复发。
[Objective] To explore the risk factors that affect the recurrence of giant-type early cervical cancer. [Methods] A retrospective analysis of 324 cases of early-stage cervical cancer patients with recurrent relapse-related treatment and pathological factors. [Results] The total recurrence rate was 39.0%, and the 5-year survival rate was 62.5%. Univariate analysis showed that neoadjuvant chemotherapy, pathological grading, pelvic lymph node metastasis, vascular invasion, surgical margin cancer cell residue, deep myometrial cancer cell infiltration, and paracancer cell infiltration were closely related to tumor recurrence (P <0.05). Cox multivariate analysis showed that the degree of cancer cell differentiation is low, deep myometrial cancer cell invasion and pelvic lymph node metastasis are the main risk factors (P <0.05). [Conclusion] The treatment of bulky early cervical cancer should emphasize the comprehensive treatment to reduce the recurrence.