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流行病学调查、动物实验和药物治疗都提示钙和高血压关系密切。McCarron 发现钙摄入量不足会使血压升高,他主张增加饮食中钙量,以防治高血压,但对此观点尚有争议。高血压存在细胞膜对 Ca~(++)转运障碍如质膜对 Ca~(++)通透性增加、ATP 依赖的 Ca~(++)转运能力降低、质膜对 Ca~(++)结合能力降低等。上述异常使细胞内游离 Ca~(++)增高,后者可能是高血压发病的最后共同途径。
Epidemiological investigation, animal experiments and drug treatment suggest that calcium and hypertension are closely related. McCarron found that lack of calcium intake will make blood pressure, he advocated increasing dietary calcium, to prevent high blood pressure, but this view is still controversial. Hypotension has the effect of cell membrane on Ca ~ (++) transport disorder such as Ca ~ (++) permeability increase, ATP - dependent Ca ~ (++) transport ability decrease, Ca ~ (++) Lower binding capacity and so on. These abnormalities make intracellular free Ca ~ (++) increased, the latter may be the last common pathway of hypertension.