牙周炎是牙周支持组织的慢性感染性疾病,除了牙周致病菌的直接作用,机体针对致病菌的免疫反应失调是造成牙周组织破坏的主要原因,牙菌斑聚集在牙龈附近的牙表面,使口腔沟内上皮和结合上皮与定植菌的代谢产物、酶和表面成分接触,细菌和细菌成分特别是脂多糖还能通过结合上皮和袋上皮进入结缔组织和血管,激发上皮细胞产生致炎细胞因子和其他炎症化学介质,开始组织内的炎症反应,包括补体激活,肥大细胞及中性粒细胞的 Periodontitis is a chronic infectious disease of periodontal support tissues. In addition to the direct role of periodontal pathogens, the body’s immune response to pathogenic bacteria is the main cause of periodontal tissue destruction, and plaque accumulates near the gums Of the tooth surface, the oral gut epithelium and the bound epithelium with the metabolites of bacteria, enzymes and surface composition of contact, bacterial and bacterial components, especially lipopolysaccharide can also enter the epithelium and the bag epithelial access to connective tissue and blood vessels, stimulate the epithelial cells Production of proinflammatory cytokines and other inflammatory chemical mediators, initiating inflammatory reactions in tissues, including complement activation, mast cells and neutrophils