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目的:探讨参乌合剂对舒张功能不全心力衰竭的治疗效果。方法:选符合纳入标准的舒张功能不全心力衰竭患者120例,随机分为治疗组、对照组各60例。治疗组在西医常规治疗基础上,予参乌冠心冲剂;对照组仅予西医常规治疗。疗程1个月。结果:治疗组显效35例,有效20例,无效5例,总有效率为91.67%(95%CI=84.68%～98.66%);对照组显效26例,有效18例,无效16例,总有效率为73.33%(95%CI=62.14%～84.52%);两组综合疗效比较,有显著性差异(u=2.0283,P=0.0427);同时,治疗组治疗后症状积分、超声心动图A峰值较对照组显著下降(P<0.05);超声心动图E/A值明显升高(P<0.01)。结论:参乌合剂合西医常规治疗舒张功能不全心力衰竭较单纯西医常规治疗的疗效为优,其收益为OR=0.25(95%CI=0.08～0.74),NNT=5(95%CI=3.13～21.10)。并可改善舒张末期心肌的顺应性,改善心功能。
Objective: To investigate the therapeutic effect of Shenwu mixture on heart failure with diastolic dysfunction. Methods: A total of 120 patients with congestive heart failure who were included in the standard were randomly divided into treatment group and control group with 60 cases each. The treatment group was treated with Wuxuanxin Granule on the basis of conventional treatment of Western medicine, while the control group was given only conventional treatment of Western medicine. Treatment for 1 month. Results: In the treatment group, 35 cases were markedly effective, 20 cases were effective and 5 cases were ineffective. The total effective rate was 91.67% (95% CI = 84.68% ~ 98.66%). In the control group, 26 cases were markedly effective, 18 cases were effective and 16 cases were ineffective. The effective rate was 73.33% (95% CI = 62.14% -84.52%). There was significant difference between the two groups (u = 2.0283, P = 0.0427) (P <0.05). E / A value of echocardiography was significantly higher than that of control group (P <0.01). CONCLUSIONS: Shenwukang combined with western medicine routine treatment of diastolic dysfunction is superior to conventional Western medicine in the treatment of heart failure. The benefits are 0.25% (95% CI = 0.08-0.74), NNT = 5 (95% CI = 3.13 ~ 21.10). And can improve the end-diastolic myocardial compliance, improve cardiac function.