目的:了解NF-κB在BXSB狼疮性肾炎小鼠肾组织中的表达及意义。方法:取BXSB狼疮性肾炎小鼠(即LN组)与C57BL/6小鼠(即对照组)各10只,应用免疫组织化学SP法检测肾组织中NF-κB的表达,并与病理学指标行等级相关分析。结果:LN组小鼠肾组织中NF-κB表达较对照组显著增高(P<0.05);NF-κB在肾小球和肾小管均有表达,但以肾小管表达更为显著;肾小球NF-κB阳性细胞数、NF-κB阳性肾小管数与肾组织活动指数呈高度正相关。结论:NF-κB可能参与了LN小鼠的发病机制,检测其在肾组织中的表达可作为反映狼疮肾组织活动病变的参考指标之一。 Objective: To investigate the expression and significance of NF-κB in renal tissues of BXSB-induced lupus nephritis mice. Methods: Ten BXSB lupus nephritis mice (LN group) and C57BL / 6 mice (control group), 10 were used to detect the expression of NF-κB in renal tissue by immunohistochemical SP method. Line-level correlation analysis. Results: The expression of NF-κB in LN group was significantly higher than that in control group (P <0.05). The expression of NF-κB in glomeruli and tubules, The number of NF-κB positive cells, the number of NF-κB positive tubules and the activity index of renal tissue were highly positively correlated. CONCLUSION: NF-κB may be involved in the pathogenesis of LN mice and its expression in renal tissue can be used as a reference index to reflect the pathological changes of lupus renal tissues.