论文部分内容阅读
目的探讨肿瘤抗原125(CA125)与肿瘤抗原19-9(CA19-9)检测对妇科肿瘤诊断的价值。方法收集来福建省立金山医院就诊的经病理组织学确诊为妇科肿瘤的患者96例,其中良性组21例、恶性组75例;同时选取42例健康体检的健康女性作为对照组。分别检测血清CA125与CA19-9水平,然后对恶性组、良性组和对照组进行比较,并对不同恶性肿瘤患者血清CA125及CA19-9阳性率进行分析。结果恶性组的CA125及CA19-9水平均高于对照组和良性组,良性组的CA125及CA19-9水平均高于对照组,差异均有统计学意义(P<0.05);卵巢癌和子宫内膜癌患者的CA125阳性表达率高于宫颈癌组,差异有统计学意义(P<0.05);CA125和CA19-9联合检测对妇科肿瘤诊断的准确性高于单独检测CA125或CA19-9。结论 CA125、CA19-9的检测有助于妇科肿瘤的诊断和鉴别诊断,联合检测的诊断价值更高。
Objective To investigate the value of tumor antigen 125 (CA125) and tumor antigen 19-9 (CA19-9) in the diagnosis of gynecological tumors. Methods Totally 96 patients with pathological diagnosis of gynecological tumor were collected from Li Jinshan Hospital of Fujian Province. Among them, 21 were benign group and 75 were malignant group. Forty-two healthy women were selected as control group. The levels of serum CA125 and CA19-9 were detected respectively. Then the malignant group, benign group and control group were compared, and the positive rates of serum CA125 and CA19-9 in different malignant tumors were analyzed. Results The levels of CA125 and CA19-9 in the malignant group were significantly higher than those in the control group and the benign group. The levels of CA125 and CA19-9 in the benign group were significantly higher than those in the control group (P <0.05) The positive rate of CA125 in endometrial carcinoma patients was significantly higher than that in cervical cancer patients (P <0.05). The accuracy of combined detection of CA125 and CA19-9 in gynecologic oncology was higher than that of CA125 or CA19-9 alone. Conclusion The detection of CA125 and CA19-9 is helpful for the diagnosis and differential diagnosis of gynecologic oncology. The diagnostic value of combined detection is higher.