自Einhorn和D on ohue采用顺氯氨铂、长春花硷、争光霉素(简称PBV)的综合性化学疗法以来,已成为对扩散的睾丸生殖细胞癌的标准化学疗法。接受该疗法的病例中70～80%可得到完全缓解,其中95%的病人能生存5年以上。因此,避免这一疗法的并发症已成为长期的研究课题。使用烷化剂治疗,尤其是与照射法结合治疗时所产生已知的并发症是急性非淋巴细胞白血病(ANLL)。烷化剂以及放射疗法或者两者共同使用治疗睾丸生殖细胞瘤的病人中,已发现会出现急性白血病,但直到现在没有人正式报道 Since Einhorn and D on ohue have been combined with cisplatin, vinblastine, bleomycin (PBV) for general chemotherapy, they have become standard chemotherapies for proliferative testicular germ cell cancers. 70 to 80% of the cases receiving the therapy are completely relieved, with 95% of patients surviving for more than 5 years. Therefore, to avoid the complications of this therapy has become a long-term research topic. A known complication that occurs with alkylating agents, especially when combined with irradiation, is acute non-lymphocytic leukemia (ANLL). Alkylating agents and radiotherapy, or both, for the treatment of testicular germinomas, acute leukemia has been found but no one has officially reported it