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目的探讨鲑鱼降钙素(密盖息)治疗骨转移瘤疼痛和血清钙的临床疗效。方法将40例有骨转移的恶性肿瘤患者随机分为2组,治疗组予密盖息,对照组予口服盐酸吗啡控释片,60mg/d。治疗结束后评价骨痛缓解程度、Karnofsky评分及血钙变化。结果治疗组骨痛完全缓解40.0%(8/20例),Karnofsky评分增加10分以上者为70.0%(14/20例),血钙降至正常者80.0%(16/20例);对照组骨痛完全缓解率10%(2/20例),Karnofsky评分增加10分以上者15.0%(3/20例),血钙无明显变化,两组比较差异有统计学意义(P<0.05)。结论密盖息治疗骨转移瘤有止痛、改善患者生活质量,降低血钙,预防并减少骨相关事件发生的作用。
Objective To investigate the clinical efficacy of salmon calcitonin (close lid) in the treatment of bone metastases pain and serum calcium. Methods Forty patients with malignant tumor with bone metastasis were divided into two groups at random. The treatment group was treated with close lid and the control group was orally administered morphine hydrochloride controlled release tablets 60mg / d. Pain relief, Karnofsky score, and serum calcium change were evaluated after treatment. Results The treatment group had 40.0% (8/20%) complete remission of bone pain, 70.0% (14/20 cases) with Karnofsky score increased more than 10 points and 80.0% (16/20 cases) with normal serum calcium. The control group Complete pain relief rate was 10% (2/20 cases), Karnofsky score increased more than 10 points 15.0% (3/20 cases), serum calcium had no significant change, the difference between the two groups was statistically significant (P <0.05). Conclusions MiGaiYi can relieve bone metastases, relieve pain, improve quality of life, decrease blood calcium, and prevent and reduce the incidence of bone-related events.