HLA为人的主要组织相容性系统,它有显著的多态性,这种多态性的差异决定了免疫应答的个体差异。因而人们推测HLA系统特定的等位基因可能对某些疾病的发生起着重要的作用,并开始对所有的疾病进行相关性检查。迄今为止已报道了4000多例,所涉及的疾病达500多种。不过,即便是确实存在“相关”的病例,其相关性的机制多数仍不清 HLA is a major histocompatibility system in humans. It has significant polymorphisms, and the differences among these polymorphisms determine the individual differences in immune responses. Therefore, it is speculated that HLA-specific alleles may play an important role in the occurrence of certain diseases, and began to conduct a correlation test for all diseases. To date, more than 4,000 cases have been reported, involving more than 500 kinds of diseases. However, most of the related mechanisms are still unclear even if there are “related” cases