环扁桃酸酯(Cyclandelate),化学名:(±)顺式3,3,5-三甲基环己醇(±)扁桃酸酯,是一种在国外研究开发较早的周围血管扩张剂,可防治脑血管与四肢末梢血管障碍性疾病,主要适用于脑动脉硬化症等,疗效显著。此药从五十年代起,先后在欧美及日本上市。国内也已研制成功并经技术鉴定。现就其在合成中所产生的质量问题——杂质的来源及其控制方法作一论述。环扁桃酸酯系由(±)顺式3,3,5-三甲 Cyclodextrin (Cyclandelate), chemical name: () cis 3,3,5-trimethylcyclohexanol (±) mandelate, is a research and development in the earlier peripheral vasodilators, Can prevent cerebrovascular and peripheral vascular disorders, mainly for cerebral arteriosclerosis, with significant effect. The medicine from the fifties, has in Europe and the United States and Japan. China has also been successfully developed and technical appraisal. Now on the quality problems arising in the synthesis - the source of impurities and their control methods are discussed. Cyclofenate is (±) cis 3,3,5-trimethylenes