目的优选明眸滴丸的最佳制备工艺。方法采用正交试验法,以丸重变异系数、溶散时限、滴丸硬度作为检测指标,优选滴丸成型工艺。结果滴丸最佳制备工艺条件为,以聚乙二醇6000(PEG6000)为基质,药物与基质配比为1∶1.5,冷却液温度为8℃。结论明眸滴丸制备工艺简便可行、稳定合理,评分指标客观、可靠、合理。 The purpose of optimizing the best preparation pills dripping pills. Methods Orthogonal test was used to measure the coefficient of variation of pellet weight, dissolution time and hardness of dropping pills as dropping pills. Results The optimal preparation conditions for dropping pills were as follows: polyethylene glycol 6000 (PEG6000) was used as the matrix, the ratio of drug to matrix was 1: 1.5, and the temperature of the coolant was 8 ℃. Conclusion Mingyou drop pills preparation process is simple and feasible, stable and reasonable, objective, objective and reliable indicators.