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目的:研究10号染色体同源丢失性磷酸酶张力蛋白基因(PTEN)表达与舌鳞癌(TSCC)临床病理特点的关系。方法:应用免疫组化SABC法检测PTEN蛋白在74例TSCC组织和15例癌旁正常黏膜中的表达。采用SPSS11.5统计软件包,分别应用Mann-WhitneyU法、χ2检验及Fisher精确概率检验,以P<0.05作为差异有显著意义。结果:PTEN阳性表达率在癌旁正常组织及TSCC组织中分别为100%、66.2%,差异有显著性(P<0.05)。PTEN的表达水平与肿瘤T分期、病理学分级无关(P>0.05),与淋巴结转移显著相关(P<0.05)。结论:PTEN蛋白表达与TSCC的淋巴结转移有关。
Objective: To study the relationship between the expression of PTEN gene on chromosome 10 and the clinicopathological features of tongue squamous cell carcinoma (TSCC). Methods: Immunohistochemical SABC method was used to detect the expression of PTEN protein in 74 TSCC tissues and 15 adjacent normal mucosa. Using SPSS11.5 statistical software package, respectively, Mann-WhitneyU method, χ2 test and Fisher exact test, with P <0.05 as the difference was significant. Results: The positive expression rate of PTEN was 100% and 66.2% in normal tissues and TSCC tissues, respectively. The difference was significant (P <0.05). The expression of PTEN was not related to tumor T stage and pathological grade (P> 0.05), but significantly correlated with lymph node metastasis (P <0.05). Conclusion: PTEN protein expression is related to lymph node metastasis in TSCC.