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神经母细胞瘤(neuroblastoma,NB)是婴幼儿最常见的颅外实体肿瘤,来源于未分化的交感神经节细胞,恶性程度高,占恶性肿瘤的8%~10%。早期易发生转移[1],常见的转移部位为骨、骨髓、淋巴结、肝脏、皮肤,少见有肺和脑实质,且肺转移是预后不良的标志[2]。笔者总结经武警某部医院收治的4例伴肺转移NB患儿的临床特点及生物学特征,旨在分析肺转移途径,阐述疗效,评估预后。1资料与方法
Neuroblastoma (NB) is the most common extracranial solid tumor in infants and young children. It is derived from undifferentiated sympathetic ganglion cells and has a high degree of malignancy, accounting for 8% -10% of malignant tumors. Early metastasis [1], the common site of metastasis of bone, bone marrow, lymph nodes, liver, skin, rare lung and brain parenchyma, and lung metastasis is a sign of poor prognosis [2]. The author summarizes the clinical features and biological characteristics of 4 children with lung metastasis and NB treated in a certain military hospital of Armed Police Force. The aim is to analyze the pathways of lung metastasis, to describe the curative effect and evaluate the prognosis. 1 data and methods