B淋巴细胞刺激因子(BLyS)是Shu等[1-4]于1999年首先发现并克隆的一种新的细胞因子,是肿瘤坏死因子(TNF)家族的第13位成员。BLyS作为B淋巴细胞的共刺激因子,参与体液免疫调控,在维持B细胞动态平衡中发挥重要作用。在生理条件下,BLyS不仅可诱导B淋巴细胞的增生,分化及存活延长[5- B lymphocyte stimulating factor (BLyS) is a new cytokine discovered and cloned by Shu et al [1-4] in 1999 and is the 13th member of the tumor necrosis factor (TNF) family. As a costimulatory factor of B lymphocytes, BLyS is involved in the regulation of humoral immunity and plays an important role in maintaining the homeostasis of B cells. Under physiological conditions, BLyS can not only induce the proliferation, differentiation and survival of B lymphocytes [5-