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目的探讨凯西莱对慢性血吸虫肝病患者服用抗结核药致肝损害的预防作用。方法117例按2HREZ/4HR短期强化抗结核方案服用抗结核药的慢性血吸虫肝病患者,随机分成两组,治疗组62例中,住院患者凯西莱冻干粉针0.2g加入5%葡萄糖液中静脉滴注,每天1次;门诊患者凯西莱片0.2g口服,每天3次。对照组55例患者给复方益肝灵片4片口服,每天3次。结果治疗组肝损害发生率16.13%,对照组肝损害发生率43.64%,两组比较差异有统计学意义(χ2=10.697,P=0.001);治疗组肝功能指标(丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素)明显好于对照组,两组治疗后比较差异有统计学意义(P<0.05)。结论凯西莱对慢性血吸虫肝病患者服用抗结核药所致的肝损害有较好的预防作用。
Objective To investigate the preventive effect of Kesilai on liver damage induced by anti-TB drugs in patients with chronic schistosomiasis liver disease. Methods A total of 117 patients with chronic schistosomiasis liver disease treated with 2HREZ / 4HR short-term intensive anti-TB regimen were randomly divided into two groups. Among the 62 patients in the treatment group, 0.2 g of Ketailai lyophilized powder for inpatients was added to 5% glucose solution Intravenous infusion, 1 times a day; outpatient Casey Silene tablets 0.2g orally, 3 times a day. The control group of 55 patients to compound Yiganling tablets 4 orally 3 times a day. Results The incidence of liver damage was 16.13% in the treatment group and 43.64% in the control group. There was significant difference between the two groups (χ2 = 10.697, P = 0.001). The liver function indexes (alanine aminotransferase, Aspartate aminotransferase, total bilirubin) was significantly better than the control group, the difference between the two groups after treatment was statistically significant (P <0.05). Conclusions Kesilai has a good preventive effect on liver damage caused by taking anti-TB drugs in patients with chronic schistosomiasis liver disease.