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目的 探讨碘12 5(12 5I)新型粒子永久植入治疗恶性肿瘤的临床疗效。方法 对 2 5例中晚期原发性实体瘤、局限性转移癌 ,并经放疗、化疗和其它治疗难以控制的病人。配合应用TPS、B超及CT ,经皮穿刺永久植入12 5I粒子进行近距离放疗。植入粒子后经CT检查布粒情况 ,每 2 - 4周采用胸片、CT及体表肿瘤测量观察临床治疗效果。结果 粒子分布满意率 88.0 % (2 2 / 2 5 ) ;近期总有效率 84 .0 % (2 1/ 2 5 ) ;其中CR 2 8.0 % (7/ 2 5 ) ;PR 5 6 .0 % (14 / 2 5 ) ;NR 16 .0 % (4 / 2 5 )。出现轻度并发症 4例 (16 .0 % )。结论 此技术简便易行 ,适应征广 ,安全有效 ,无污染易防护 ,为恶性肿瘤的综合治疗增添了新手段
Objective To investigate the clinical effect of permanent implantation of iodine 125 (125 I) particles in the treatment of malignant tumors. Methods Twenty-five patients with advanced solid tumors of the middle and advanced stages, localized metastatic carcinoma, and patients refractory to radiotherapy, chemotherapy and other therapies. With the application of TPS, B ultrasound and CT, percutaneous implantation of permanent implant 12 5I particles for brachytherapy. Implantation of particles by CT examination of the situation of cloth, every 2 - 4 weeks using chest radiography, CT and body surface tumor measurement to observe the clinical effect. Results The satisfactory rate of particle distribution was 88.0% (2 2/2 5) and the total effective rate was 84 .0% (2 1/2 5) in the recent period. CR 2 8.0% (7/2 5), PR 5 6 .0% 14/2 5); NR 16.0% (4/2 5). There were 4 mild complications (16.0%). Conclusion This technique is simple, easy to adapt to the disease, safe and effective, without pollution and easy protection, which adds new methods to the comprehensive treatment of malignant tumors