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肿瘤的生长、侵袭和转移依赖丰富的血供。新生血管不仅向肿瘤组织输送营养物质和排泄代谢废物,而且是肿瘤细胞转移的主要环节之一。卵巢癌恶性程度高、易转移、预后差,与癌组织血管丰富关系密切。表皮生长因子受体(EGFR)与肿瘤的发生、发展及恶性行为关系密切,其异常表达和活化,能增强血管生成分子的表达,其介导的信号转导在血管生成中发挥关键作用。血管内皮生长因子(VEGF)对卵巢癌血管内皮细胞的增殖迁移及腹水产生发挥重要作用,是促进卵巢癌血管生成的关键因子,而EGFR可以通过上调VEGF的表达影响肿瘤的血管生成。
Tumor growth, invasion and metastasis rely on a rich blood supply. Neovascularization is not only the delivery of nutrients and excretion of metabolic waste to the tumor tissue, but also one of the main aspects of tumor cell metastasis. Ovarian cancer has a high degree of malignancy, easy metastasis and poor prognosis, which is closely related to the richness of cancer tissues. Epidermal growth factor receptor (EGFR) is closely related to tumorigenesis, development and malignant behavior. Aberrant expression and activation of EGFR enhances the expression of angiogenic molecules, and its signal transduction plays a key role in angiogenesis. Vascular endothelial growth factor (VEGF) plays an important role in the proliferation and migration of ovarian cancer vascular endothelial cells and ascites production, and is a key factor to promote angiogenesis in ovarian cancer. EGFR can affect tumor angiogenesis by up-regulating the expression of VEGF.