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本文采用免疫组化方法,对10例胃溃疡癌变,79例慢性胃溃疡和161例溃疡型胃癌粘膜进行对比研究。结果:中、重度不典型增生检出率三者间有非常显著差异(P<0.001),溃疡癌变者主要发生于被覆上皮;进展期胃癌不完全大肠型肠化(36％),明显高于胃溃疡癌变组(16.60％)和慢性胃溃疡组(5.25％)。CEA阳性率:癌组织为69.62％,不典型增生为30.64％,正常胃粘膜阴性。上述结果提示,当慢性胃溃疡旁粘膜出现中度以上不典型增生伴不完全大肠型肠化时应警惕癌的发生。
In this paper, immunohistochemical methods were used to compare 10 cases of gastric ulceration, 79 cases of chronic gastric ulcer and 161 cases of gastric ulcer mucosa. Results: There was a significant difference in the detection rate of moderate and severe atypical hyperplasia (P<0.001), ulceration and canceration mainly occurred in the covered epithelium, and incomplete intestinal inflammation in advanced gastric cancer (36%). Gastric ulcer cancer group (16.60%) and chronic gastric ulcer group (5.25%). The positive rate of CEA was 69.62% in cancer tissues, 30.64% in atypical hyperplasia, and negative in normal gastric mucosa. The above results suggest that the appearance of cancer should be vigilant when moderately above atypical hyperplasia with incomplete colonic intestinal metaplasia occurs in the adjacent mucosa of chronic gastric ulcer.