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前列腺素E_2(PGE_2)和系列类似物在动物研究中均显示有很强的细胞保护和抗胃酸分泌作用。用于胃溃疡和十二指肠溃疡患者的临床试验表明,这些药物有与西米替丁等效的加速溃疡愈合的作用。但PGE_2口服活性很短暂,早期发展的类似物又多副作用,直到1985年才先后有米索前列醇、恩前列醇和罗沙前列醇上市。大剂量前列腺素类药物由于刺激小肠生成大量的液体而引起腹泻,但是其类似物——dimoxaprost在动物和人体均很少引起腹泻。此药除了治疗胃溃疡和十二指肠溃疡外,由于具有细胞保护作用,能对抗非甾体抗炎药抑制内源性前列腺素合成而形成溃疡
Prostaglandin E 2 (PGE 2) and a series of analogues show strong cytoprotection and anti-gastric acid secretion in animal studies. Clinical trials in patients with gastric ulcer and duodenal ulcer show that these drugs have the same effect of accelerating ulcer healing as cimetidine. However, PGE 2 oral activity is very short, early development of analogs and more side effects, until 1985 there has been misoprostol, enmaprost and rosiglitazone market. High-dose prostaglandins cause diarrhea by stimulating the large intestine to produce large amounts of fluid, but the analogue, dioxoxaprost, rarely causes diarrhea in both animals and humans. In addition to the treatment of gastric ulcer and duodenal ulcer, the drug has cytoprotective effects against non-steroidal anti-inflammatory drugs against endogenous prostaglandin synthesis and ulceration